Serum and synovial fluid adenosine deaminase activity in patients with rheumatoid arthritis and osteoarthritis
Mehrnoush Hassas Yeganeh MD, Seyyed Mohammad Qoreishy MD*
Shahid Beheshti University of Medical Sciences, Tehran, Iran
* Corresponding Author
Introduction: Adenosine deaminase (ADA) is an enzyme involved in purine metabolism and plays a significant role in the immune system. In this study, we try to assess the reliability of the serum and synovial levels of adenosine deaminase (ADA) in differentiating rheumatoid arthritis from osteoarthritis.
Materials and methods: We selected 15 patients with rheumatoid arthritis and 15 osteoarthritis patients to enter the study. Adenosine deaminase activity was determined in paired samples of serum and synovial fluid taken from patients with rheumatoid arthritis and osteoarthritis.
Results: The results showed a statistically significant difference between ADA levels in joint effusion of patients with rheumatoid arthritis and osteoarthritis (p<0.001). Increased activity was found in the synovial fluid taken from patients with rheumatoid disease. Synovial fluid taken from patients with osteoarthritis did not show significantly raised adenosine deaminase activity as compared with that of normal controls.
Conclusion: We concluded that synovial total ADA assay could be a sensitive and specific test, being suitable for rapid diagnosis of rheumatoid effusions.
Keywords: Adenosine deaminase (ADA), Purine metabolism, Rheumatoid arthritis, Serum, Synovial fluid, Osteoarthritis